16-P002 The developmental mutant talpid3 lacks primary cilia
نویسندگان
چکیده
منابع مشابه
16-P002 The developmental mutant talpid3 lacks primary cilia
Marc A. Willaredt, Kerstin Hasenpusch-Theil, Humphrey Gardner, Igor Kitanovic, Vera Hirschfeld-Warneken, Christian Gojak, Karin Gorgas, C. Lulu Bradford, Joachim Spatz, Stefan Woelfl, Thomas Theil, Kerry L. Tucker 1 Interdisciplinary Center for Neurosciences, University of Heidelberg, Heidelberg, Germany 2 Dept. of Anatomy, University of Heidelberg, Heidelberg, Germany 3 Centres for Neuroscienc...
متن کاملLoss of cilia causes embryonic lung hypoplasia, liver fibrosis, and cholestasis in the talpid3 ciliopathy mutant
Sonic hedgehog plays an essential role in maintaining hepatoblasts in a proliferative non-differentiating state during embryogenesis. Transduction of the Hedgehog signaling pathway is dependent on the presence of functional primary cilia and hepatoblasts, therefore, must require primary cilia for normal function. In congenital syndromes in which cilia are absent or non-functional (ciliopathies)...
متن کامل11-P012 Left/right axis specification in the cilia mutant talpid3
Comparison between related species is a successful approach to uncover conserved and divergent principles of development. Here we studied the pattern of epithalamic asymmetry in zebrafish and medaka, two related teleost species with 115–200 million-year of independent evolution. We found that these species share a strikingly conserved overall pattern of asymmetry in the parapineal–habenular–int...
متن کاملDevelopmental Abnormalities in the Trunk and Limbs of the Talpid3 Mutant of the Fowl.
THREE talpid mutants have been described in the fowl, all of which are characterized by lethal embryonic abnormalities. As explained in a previous paper (Ede & Kelly, 1964), Cole's talpid and talpid are similar in all essential respects and show striking abnormalities in the head region, whereas talpid has a relatively normal head. In all three, embryos surviving to 11 days and over show the fo...
متن کاملThe Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation.
The chicken talpid(3) mutant, with polydactyly and defects in other embryonic regions that depend on hedgehog (Hh) signalling (e.g. the neural tube), has a mutation in KIAA0568. Similar phenotypes are seen in mice and in human syndromes with mutations in genes that encode centrosomal or intraflagella transport proteins. Such mutations lead to defects in primary cilia, sites where Hh signalling ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.693